The Arizona Cardinals won only four games last season and have the blessing of opening up their 2024 schedule with a cross country trip against the Buffalo Bills.
That is how week one of the 2024 NFL season will kickoff, and for the Arizona Cardinals they are the second biggest underdogs of the opening weekend so far according to our friends at DraftKings Sportsbook.
The Arizona Cardinals open as seven-point underdogs against the Bills for week one.
Only the New England Patriots open up as bigger dogs, as they are eight-point road dogs to the Cincinnati Bengals.